We performed CVS for suspected Duchenne Muscular Dystrophy (DMD) in a fetus with a low-risk NT screening but a hypoplastic nasal bone. While awaiting the DMD results, the initial FISH report revealed Trisomy 21 (T21). This case underscores the importance of thorough evaluation: even with low-risk NT, subtle markers like a hypoplastic nasal bone can be crucial. Genetic testing helps uncover unexpected conditions, guiding better counseling and management for families.